Longitudinal Changes in Airway Remodeling and Air Trapping in Severe Asthma
نویسندگان
چکیده
منابع مشابه
Epithelial cell proliferation contributes to airway remodeling in severe asthma.
RATIONALE Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction. OBJECTIVES To evaluate if there are structural and functional differences in the airway epithelium in severe asthma associated with airway remodeling. METHODS In bronchial biopsies from 21 normal subjects, 11 subjects with chronic bronchitis, 9 subjects with mild as...
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Asthma is a chronic inflammatory disease characterized by reversible airflow limitation and airway hyperresponsiveness. Persistent inflammation in airway tissues may lead to structural changes known as airway remodeling and consequently airway obstruction that is not fully reversible and progressive loss of lung function over time. It is generally accepted that airway remodeling is closely rela...
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ژورنال
عنوان ژورنال: Academic Radiology
سال: 2014
ISSN: 1076-6332
DOI: 10.1016/j.acra.2014.05.001